Despite the full desire to derubricate transsexualism, by the scientific community, the author of this work is strongly skeptical, taking into account the neurobiological results published so far, like homosexuality and bisexuality, and clinical results regarding comorbidity profiles with depressive, anxious, phobic, obsessive, post-traumatic, food, psychotic and personality disorders (with a higher incidence on borderline disorder, narcissistic and histrionic). A very controversial and not statistically relevant and significant case was recorded in 2014, in which the patient appears to have undergone a trend conversion, from dysphoric to heterosexual male, following an epileptic state. This circumstance seems to reinforce the neurobiological and endocrinological hypothesis of dysphoria, as one of the primary causes.